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KMID : 1100220060050020043
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Dementia and Neurocognitive Disorders
2006 Volume.5 No. 2 p.43 ~ p.47
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Serum Transthyretin Expression Levels in Patients with Alzheimer’s Disease
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Sohn Ji-Hoon
Hong Hyun-Joo
Suh Dae-Keun
Kim Man-Ho
Mook In-Hee
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Abstract
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Background: Amyloid plaques, composed of the sticky Aβ peptide, is a major neurological feature of Alzheimer’s disease (AD). Lately, several lines of evidence have suggested that transthyretin (TTR), a 55 kDa homotetrameric protein, is able to bind soluble Aβ preventing amyloid fibrillization in vitro. Attenuated production of TTR could therefore be related to the pathogenesis of AD. In the present study, the levels of serum TTR in AD patients were compared with healthy normal controls. The correlation between MMSE score and serum TTR levels was also analyzed to investigate whether the levels of serum TTR were related to the cognitive dysfunction of individuals.
Methods: Blood sera were collected from 28 patients with AD and from the same number of healthy controls. The level of serum TTR was determined by immunoblotting. Statistical differences between AD patients and normal controls were analyzed and noted.
Results: The levels of serum TTR were markedly decreased in patients with AD (p>0.0001 ) compared with controls. Moreover, serum TTR levels showed a significant correlation (p<0.0001) with mini-mental state exam (MMSE) score.
Conclusions: The present study is the first report that shows a significant difference in the levels of serum TTR between AD patients and normal controls, suggesting the possibility of TTR as a putative biomarker for AD.
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KEYWORD
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Alzheimer’s disease, Transthyretin (TTR), Serum, Biomarker
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